Oxidative trifluoromethylation and fluoroolefination of unactivated olefins
The fluorine-containing organic compounds are becoming privileged in medicinal chemistry.Described herein is a mild and efficient method for the radical addition of olefins with TMS-CF3 and TMS-CF2R to deliver various a-fluorinated ketones and α-fuoroolefinated ketone analogues.Fluorine, emerged as a ”magic element” in pharmaceuticals, agrochemicals and functional materials,has become more and more significant for a large range of applications.”1” The unique physical and chemical advantages conferred by the C-F bond usually results in enhanced membrane permeability,elevated electronegativity and oxidation resistance.”2” Among them, the CF3 unit is of extensive interest owing to its strong electron-withdrawing power and high lipophilicity.Hence, the development of new synthetic methods for the direct installation of CF3-containing small molecules has already become one of the hottest fields in modem organic chemistry.
Yebin Wu Chun Cai
Chemical Engineering College, Nanjing University of Science and Technology,200 Xiao Ling Wei, Nanjing 210094, People”s Republic of China
国内会议
南京
英文
196-201
2016-12-06（万方平台首次上网日期，不代表论文的发表时间）