Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation
Cholestasis is a clinically significant symptom and widely associated with liver diseases, however, there are very few effective therapies for cholestasis.Danning tablet (DNT, a Chinese patent medicine preparation) has been clinically used to treat human liver and gallbladder diseases for more than 20 years in China.However, which ingredients of DNT contributed to this beneficial effect and their mechanistic underpinnings have been largely unknown.In the present study, we discovered that DNT not only demonstrated greater benefits for cholecystitis patients after cholecystectomy surgery in clinic but also showed protective effect against alpha-naphthylisothiocyanate (ANIT)-induced cholestasis model in rodent.Curcumin, one major compound derived from DNT, exerted the protective effect against cholestasis through farnesoid X receptor (FXR), which has been focused as potential therapeutic targets for treating cholestasis.The underlying mechanism of curcumin against cholestasis was restoring bile acid homeostasis and antagonizing inflammatory responses in a FXR-dependent manner and in turn contributed to overall cholestasis attenuation.Collectively, curcumin can be served as a potential treatment option for liver injury with cholestasis.
Fan Yang Xiaowen Tang Lili Ding Yue zhou Qiaoling Yang Junting Gong Guangyun Wang Zhengtao Wang Li Yang
The MOE Key Laboratory for Standardization of Chinese Medicines and the SHTCM Key Laboratory for New The MOE Key Laboratory for Standardization of Chinese Medicines and the SHTCM Key Laboratory for New
国内会议
南昌
英文
500-510
2016-09-27（万方平台首次上网日期，不代表论文的发表时间）