Pharmacokinetics and Disposition of Circulating Iridoids and Organic Acids in Rats Intravenously Receiving ReDuNing Injection
ReDuNing injection, prepared from a combination of Gardenia Jasminoides fruits, Lonicera japonica flower buds, and Artemisia annua aerial part, is extensively used for treatment of viral upper respiratory tract infection in China.Iridoids, organic acids, and flavonoids are probably important for the herbal injection because of their reported pharmacological properties.This study was designed to characterize pharmacokinetics and disposition of major circulating herbal compounds in rats intravenously receiving the injection.ReDuNing injection was found to contain 19 iridoids (content levels, 0.01-27.93 mM), 16 organic acids (0.04-19.06 mM), and 11 flavonoids (<0.08 mM).After dosing the injection, the iridoids geniposide, secologanic acid, secoxyloganin, genipin-l-β-gentiobioside, geniposidic acid, sweroside, and shanzhiside and the organic acids chlorogenic acid, quinic acid, cryptochlorogenic acid, and neochlorogenic acid were found to be the major circulating compounds with mean elimination half-lives of 0.2-0.9 hour, whereas other plasma compounds were at low exposure levels.These major circulating compounds exhibited small apparent volumes of distribution (0.03-0.34 l/kg).Most of the iridoids were eliminated predominantly via renal excretion of the unchanged compounds, whereas the organic acids were eliminated via methylation and sulfation and excreted into urine as the unchanged and metabolized compounds.The methylated metabolites also underwent subsequent conjugations before hepatobiliary and renal excretion.In vitro data suggested that the preceding metabolism of the organic acids in rats also occurred in humans.The current pharmaeokinetic research could serve as a crucial step in identifying the chemical basis responsible for the therapeutic action of ReDuNing injection.
Chen Cheng Feifei Du Ke Yu Fang Xu Fengqing Wang Li Li Olajide E.Olaleye Junling Yang Feng Chen Chenchun Zhong Qiongwei Liu Jing Li Zhenzhong Wang Chuan Li Wei Xiao
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Scie Jiangsu Kanion Pharmaceutical Corporation, Lianyungang, Jiangsu Province, China
国内会议
南昌
英文
30-42
2016-09-27（万方平台首次上网日期，不代表论文的发表时间）