Although emperipolesis exists in infectious liver diseases, the diagnostic value of emperipolesis in hepatitis B is not known exactly.The aim of this study was to evaluate histological characteristics and laboratory parameters of emperipolesis in hepatitis B.Totally 402 patients with hepatitis B and other liver diseases were processed in a retrospective assessment.Inflammatory severity of hepatitis B was evaluated with Ishak Scoring System.Immunofluorescent staining was performed for CD8 (T cells) , CD20 (B cells), CD56 (NK cells), CD68 (macrophages) and MPO (neutrophils).Emperipolesis was observed in 74.0% of patients with chronic hepatitis B (CHB) and 82.8% of patients with acute hepatitis B (AHB).In emperipolesis, CD8 + T cell was the main cell type.Patients with emperipolesis in CHB got high scores of inflammatory activity.Among patients with CHB, emperipolesis was present with higher serum ALT, AST and GGT levels.HBV DNA Load in patients with emperipolesis was as 10 times high as those without.HBeAb was significantly related with the evidence of emperipolesis.In hepatitis B, emperipolesis was associated with severity of liver injury.The presence of emperipolesis was an indicator of active liver inflammation.
Emperipolesis Hepatitis B ActiveLiver Inflammation CD8+T cell HBV DNA
Jiang Lina Zhou Guangde Liu Shuhong Liu Yuan Zhang Xiao Zhao Suxian Wu Liyuan Yang Mei Ma Li Sun Qiang Wang Xiaoning Zhao Jingmin
Department of Pathology and Hepatology Institution, Beijing 302 Hospital, No.100 Xisihuan Middle Roa Department of Traditional and Western Medical Hepatology, The Third Hospital of Hebei Medical Univer Institute of Molecular Immunology, School of Biotechnology, Southern Medical University,Guangzhou 51 Laboratory of Cell Engineering, Institute of Biotechnology, 20 Dongda Street,Beijing 100071, P.R.Chi Beijing Key Laboratory for Aging and Geriatrics, Institute of Geriatrics, General Hospital of Chines