Gut microbiota signatures of longevity
An aging global population poses substantial challenges to suciety.Centenarians are a model for healthy aging due to their having reached the extreme limit of life by escaping, surviving, or delaying chronic diseases.The genetics of centenarians have been extensively examined, but less is known about their gut microbiotas.Recently, Biagi et al.characterized the gut microbiota in Italian centenarians and semi-supercentenarians.Here,we compare the gut microbiota of Chinese long-living people with younger age groups, and with the results from the Italian population, to identify gut-microbial signatures of healthy aging.A total of 168 individuals from Dujiangyan and Ya”an, Sichuan province, China were enrolled in this study and assigned into two groups: a long-living group (≥90 years old), including 67 healthy centenarians and nonagenarians, and a younger age group, including 54 elderly and 47 young adults.Gut microbiotas were characterized by sequencing the V3-V4 region of the 16S rRNA gene using the Illumina MiSeq platform.Full details are provided in the Supplemental Experimental Procedures.Sequences were clustered into operational taxonomic units (OTUs) using a 97％ similarity cutoff.
Fanli Kong Yutong Hua Bo Zeng Ruihong Ning Ying Li Jiangchao Zhao
Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Farm Animal Genetic Resources Exploration and Innovation Key Laboratory of Sichuan Province, Sichuan Department of Animal Science, Division of Agriculture, University of Arkansas, Fayetteville, Arkansa
国内会议
中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
青岛
英文
232-232
2016-11-01（万方平台首次上网日期，不代表论文的发表时间）