Transplanted Human Umbilical Cord Mesenchymal Stem Cells Facilitate Lesion Repair in B6.Fas Mice
Background.Systemic lupus erythematosus (SLE) is a multisystem disease that is characterized by the appearance of serum autoantibodies.No effective treatment for SLE currently exists.Methods.We used human umbilical cord mesenchymal stem cell (H-UC-MSC) transplantation to treat B6.Fas mice.Results.After four rounds of cell transplantation, we observed a statistically significant decrease in the levels of mouse anti-nuclear, anti-histone, and anti-double-stranded DNA antibodies in transplanted mice compared with controls.The percentage of CD4+CD25+Foxp3+ T cells in mouse peripheral blood significantly increased after H-UC-MSC transplantation.Conclusions.The results showed that H-UC-MSCs could repair lesions in B6.Fas mice such that all of the relevant disease indicators in B6.Fas mice were restored to the levels observed in normal C57BL/6 mice.
Xing-hua Pan iao-qiao Song ie-jie Dai iang Yao in-xiang Wang ong-qing Pang Jie He Zi-an Li Xiao-mei Sun Guang-ping Ruan
Cell Engineering Laboratory of Yunnan Province,Kunming General Hospital of Chengdu Military Command nical College of Kunming General Hospital of Chengdu Military Command,Kunming Medical University he Institute of Medical Biology,The Chinese Academy of Medical Science and Peking Union Medical Coll
国内会议
昆明
英文
157-157
2015-09-01（万方平台首次上网日期，不代表论文的发表时间）