Engineered gadolinium-doped carbon dots for magnetic resonance imaging-guided radiotherapy of tumor
Objective: The development of nanomedicine provides unprecedented opportunities for design and fabrication of new theranostic agents against cancer.Method: In this study,we successfully constructed a novel theranostic nanoplatform based on gadolinium-doped carbon dots(Gd-doped CDs)designed specifically for magnetic resonance imaging-guided radiotherapy of tumor.Results: The as-prepared Gd-doped CDs(~nm)with dispersibility in water and stable photoluminescence were synthesized via one-step hydrothermal approach.Remarkably,they exhibited favorable biocompatibility and excellent performance in longitudinal relaxivity(r1)of 6.45 mM-1S-1 and radiosensitization enhancements.In addition,the Gd-doped CDs can be rapid accumulated in kidney and cleared out of the body from the bladder after tail vein injection,where relatively long circulation time(~6 h)in vivo endowed Gd-doped CDs with efficient tumor passive targeting.Conclusion: These studies revealed that Gd-doped CDs as both excellent T1 contrasts agent and radiosensitizer possess great promise for magnetic resonance imaging-guided radiotherapy of tumor.
MRI contrast agents gadolinium carbon dots radiotherapy
Fengyi Du Li Zhang Miaomiao Zhang Aihua Gong Qixiang Shao Chaoyang Wu
School of Medicine,Jiangsu University,Zhenjiang,212013,P.R.China Division of oncology radiation,Affiliated People Hospital,Jiangsu University,Zhenjiang,212001,P.R.Ch
国内会议
南京
英文
1-6
2015-10-16（万方平台首次上网日期，不代表论文的发表时间）