Parkin prevents Prp106-126 peptide induce toxicity in N2a cells

摘要：

Introduction: Transmissible spongiform encephalopathy’s (TSEs) are a group of fatal neurodegenerative diseases of animals and humans. These diseases are caused by the deposition of an abnormal iso-form of prion protein (PrPSc). Protein aggregation, misfolding and toxicity in the brain are the major causes of neuronal dysfunction. The Ubiquitin Proteosome System (UPS) is the major pathway that targets defective and misfolded proteins for destruction and recycling.

作者: Sher Hayat Khan Zhou Xiangmei Zhao Deming Yang Lifeng

作者单位: National Spongiform Encephalopathy Lab,College of Veterinary Medicine China Agricultural University Beijing Haidian 100193,PRChina

会议类型: 国内会议

会议名称: 中国畜牧兽医学会兽医病理学分会第二十一次学术研讨会暨中国病理生理学会动物病理生理学专业委员会第二十次学术研讨会

会议地点: 太原

会议语种:英文

页码: 22-22

在线出版日期: 2015-07-24（万方平台首次上网日期，不代表论文的发表时间）