1,8-桉油精对流感病毒性肺炎鼠的保护作用
1,8-cineol is a major monoterpene principally from eucalyptus essential oils and has been shown to exert anti-inflammatory,anti-viral and inhibitory of nuclear factor (NF)-κB effect.In the present study,we evaluated the effect of 1,8-cineol on mice infected with influenza A virus.We found that 1,8-cineol protect against influenza viral infection in mice. Moreover,1,8-cineol efficiently decreased the level of IL-4,IL-5,IL-10,and MCP-1 in nasopharyngeal washes and the level of IL-1β，IL-6,TNF-α, and IFN-γ in lung tissues of mice infected with influenza virus.The results also showed that 1,8-cineol reduced the expression of NF-κB p65, intercellular adhesion molecule (ICAM)-1 and vascular cell adhesion molecule (VCAM)-1 in lung tissues.Thus,1,8-cineol appears to be able to augment protection against IFV infection in mice via attenuation of pulmonary inflammatory responses.
病毒性肺炎 甲型流感病毒 1,8-桉油精 实验药理
栗昀 赖艳妮 王遥 刘妮 张奉学 徐培平
广州中医药大学,热带医学研究所,广州,中国
国内会议
贵州兴义
中文
127-149
2016-08-25（万方平台首次上网日期，不代表论文的发表时间）