Proteomic Profiling and Characterization of Differentially Expressed Proteins in a Novel Animal Model of Chronic Mild Stress and Breast Cancer
Breast cancer is the most common malignancy, which leads to both physical and psychological impairments.Accumulating evidence has suggested that negative mood is tightly related to initiation and progression of breast cancer.In this paper,we established a new animal model of breast cancer and chronic mild stress, and then evaluated the association between depression-like behaviors induced by chronic mild stress and breast cancer progression on the model of transgenic mice.The increasing tumor growth was largely attributable to depressive-like behaviors induced by chronic mild stress, presented as increased tumor incidence, enlarged tumor volume and relatively heavier tumor weight.Under phenomenon observed above, proteomics study using two-dimensional differential gel electrophoresis was applied to explore the involved protein changes.All these proteins were involved in breast cancer progression at varying stages.In addition, we searched the identified proteins and found that Thioredoxin 2 was the most potential marker linking depression-like behaviors with breast cancer development among the 8 candidate proteins.However, further functional studies will be conducted to confirm this finding, which may, in turn, pave a way for clinical treatment among breast cancer patients with chronic depression.
Breast cancer chronic mild stress proteomics protein profiling thioredoxin 2
Lei Jia Jianping Chen Neng Wang Zhiyu Wang Yanling Zhao Xiaofan Zhang Youzhi Sun Jieshu You Fu Peng Fei Gao
School of Chinese Medicine,Li Ka Shins Faculty of Medicine,the University of Hong Kong,Hong Kong School of Chinese Medicine,Li Ka Shins Faculty of Medicine,the University of Hong Kong,Hong Kong;Sch School of Chinese Medicine,Li Ka Shins Faculty of Medicine,the University of Hong Kong,Hong Kong;Dep 302 Military Hospital of Beijing,Beijing,China School of Chinese Medicine,the Jiangxi University of Traditional Chinese Medicine,China
国内会议
广州
英文
368-382
2016-03-26（万方平台首次上网日期，不代表论文的发表时间）