Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation

摘要：

Autophagy is an intracellular degradation process to clear up aggregated proteins or aging and damaged organelles.The Beclin1-Vps34-Atg14L complex is essential for autophagosome formation.However,how the complex formation is regulated is unclear.Here,we show that Dapper1 (Dpr1) acts as a critical regulator of the Beclin1-Vps34-Atg14L complex to promote autophagy.Dpr1 ablation in the central nervous system results in motor coordination defect and accumulation of p62 and ubiquitinated proteins.

作者: Ye-Guang Chen

作者单位: State Key Laboratory of Biomembrane and Membrane Biotechnology,Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University,Beijing 100084, China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 7-7

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）