The role of IRE1a-XBP1S in endochondral bone growth and osteoblast Differentiation

摘要：

Bone morphogenetic protein 2 (BMP2) is known to activate unfolded protein response (UPR) signaling molecules,such as BiP(IgH chain-binding protein),PERK (PKR-like ER-resistant kinase),and IRE1a.Inositol-requiring enzyme-1a (IRE1a),as one of three unfolded protein sensors in UPR signaling pathways,can be activated during ER stress.Granulin-epithelin precursor(GEP) is an autocrine growth factor that has been implicated in embryonic development,tissue repair,tumorigenesis,and inflammation.

作者: Feng-Jin Guo Zhangyuan Xiong Xiaofeng Han Fei Xia Meiling Li Zhimeng Wu Li Deng

作者单位: Department of Cell Biology and Genetics, Core Facility of Development Biology,Chongqing Medical University, Chongqing 400016, China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 11-11

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）