Intrinsic factors and neural fate commitment of ectoderm

摘要：

Cell fate determination is accomplished by the cooperation between extrinsic signals and intrinsic factors including transcription factors as well as epigenetic regulators.However,how neural induction is regulated by epigenetic factors remains largely unknown.Here,we show that transient histone deacetylation at the epiblast stage is required for the neural differentiation of mouse embryonic stem cells (mESCs).The deletion of HDAC1 in mESCs partially phenocopies the inhibition of histone deacetylation.

作者: Naihe Jing

作者单位: State Key Laboratory of Cell Biology, Institute of Biochemistry and Cell Biology,Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 20-20

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）