DNA demethylation confers competence on the genome for zygotic genome activation in zebrafish embryos

摘要：

The zygotic genome of animal embryos is transcriptionally inactive upon fertilization,and becomes active after a certain period of development.As transcription can be controlled by the presence of 5-methylcytosines (5mC) in DNA,the global DNA methylation level in an embryo may play a role in the zygotic genome activation (ZGA).In mammals,the paternal genome is rapidly demethylated immediately after fertilization through 5mC hydroxymethylation,resulting in a decrease of the global DNA methylation level of the zygote genome.

作者: Anming Meng

作者单位: State-Key Laboratory of Biomembrane and Membrane Engineering, Tsinghua-Peking Center for Life Sciences, School of Life Sciences, Tsinghua University, Beijing 100084,China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 30-30

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）