Blocking Follistatin-like 1 attenuates pulmonary fibrosis in mice

摘要：

Progressive tissue fibrosis is a cause of major morbidity and mortality.Pulmonary fibrosis is an epithelial-mesenchymal disorder in which TGF-β1 indubitably plays a central role in the process.Here we showed that follistatin-like 1 (FSTL1) regulated TGF- and BMP signaling leading to epithelial injury while it modulated TGF-,not BMP,signaling leading fibroblast activation.

作者: Yingying Dong Yan Geng Lian Li Xiaohe Li Xiaohua Yan Yinshan Fang Xinxin Li Siyuan Dong Xue Liu Xue Li Xiuhong Yang Xiaohong Zheng Ting Xie Jiurong Liang Ye-Guang Chen Huaping Dai Xinqi Liu Zhinan Yin Paul Noble Dianhua Jiang Wen Ning

作者单位: College of Life Sciences, Nankai University, Tianjin 300071, China;Model Animal Research Center, Nan College of Life Sciences, Nankai University, Tianjin 300071, China;Model Animal Research Center, Nan College of Life Sciences, Nankai University, Tianjin 300071, China State Key Laboratory of Biomembrane and Membrane Biotechnology, School of Life Sciences, Tsinghua Un Cedars-Sinai Medical Center, Department of Medicine, Los Angeles, CA 90048,USA Beijing Chao-Yang Hospital, Capital Medical University, Beijing 100020, China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 32-32

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）