Synergistic function of Kras mutation and HBx in initiation and progression of hepatocellular carcinoma in mice
Although the activation of Ras pathway is frequently observed in human hepatocellular carcinoma (HCC),the in vivo role of Ras activation in HCC initiation and progression is underdetermined.To test the consequence of Kras activation in hepatocyte,we generated a hepatocyte-specific KrasG12D transgenic mouse strain and observed spontaneous development of HCC in these mice.Remarkably,HBV X protein (HBx) expression significantly promotes the formation and malignant progression of KrasG12D-driven HCC as shown with the accelerated tumor onset,the increased tumor burden and the more poorly differentiated lesions.At the cellular level,concomitant expression of KrasG12D and HBx results in a robust increase in hepatocellular proliferation.
H Ye C Zhang B-J Wang X-H Tan W-P Zhang Y Teng X Yang
上海交通大学医学院;军事医学科学院生物工程研究所发育和疾病遗传学研究室(蛋白质组学国家重点实验室) 军事医学科学院生物工程研究所发育和疾病遗传学研究室(蛋白质组学国家重点实验室) 第二军医大学病理生理教研室
国内会议
厦门
英文
34-34
2014-07-17（万方平台首次上网日期，不代表论文的发表时间）