Role of steroid receptor coactivator 3 in bacterial colitis

摘要：

Steroid receptor coactivator 3 (SRC-3) is a transcriptional coactivator which interacts with nuclear receptors and other transcription factors to enhance their effects on target gene transcription.We recently reported that SRC-3-deficient (SRC-3-/-) mice are markedly more susceptible to Ecoil-induced septic peritonitis due to an uncontrolled overwhelming inflammation and a defect in bacterial clearance,which highlights a pivotal role of SRC-3 in the host defense system against bacterial infection.

作者: Wenbo Chen Xuqiang Lu Ming Li Pingli Mo Jianming Xu Chundong Yu

作者单位: The State key Laboratory of Cellular Stress Biology, School of Life Sciences, Xiamen University, Fujian 361102

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 56-56

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）