Unable to forget in autism susceptibility genes mutants

摘要：

To investigate whether common neurobiological mechanisms underlie effects of autism susceptibility genes,we assayed both the immediate memory and reversal memory in mutants of multiple homologous such genes in Drosophila.We found that although showing mild immediate memory defects,all these mutants displayed a serve defect in reversal learning.In other words,much pronounced alteration was observed in cognitive flexibility than in learning among all homologous autism susceptibility genes examined.To determine mechanisms underlying such behavioral alteration,we chose to focus on fragile X mental retardation gene (fmr1),encoding a RNA-binding protein.

作者: T. Dong J.He S. Wang L. Wang Y. Zhong

作者单位: School of Life Sciences, Tsinghua University, Beijing, P.R. China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 68-68

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）