Long-term artificial selection reveals a role of TCTP in autophagy in mammalian cells

摘要：

Understanding genomic variation and detecting selection signatures in a genome under selection have been great challenges for a century.In mammalian ovary,activation,development/exhaustion of primordial follicles determines reproductive success,menopause/end of female reproductive life.However,molecular mechanisms underlying oogenesis,particularly under artificial selection,are largely unknown.We report that a proteome-wide scan for selection signatures in the genome over 9,000-years of artificial pressure on the ovary revealed a general picture of selection signatures in the genome,especially genomic variations through artificial selection were detected in promoter and intron regions.

作者: Ke Chen Chunhua Huang Jia Yuan Hanhua Cheng Rongjia Zhou

作者单位: Department of Genetics, College of Life Sciences, Wuhan University, Wuhan 430072,P. R. China

会议类型: 国内会议

会议名称: 第三届“模式生物与人类健康”发育遗传学全国学术研讨会

会议地点: 厦门

会议语种:英文

页码: 70-70

在线出版日期: 2014-07-17（万方平台首次上网日期，不代表论文的发表时间）