Transcriptome analysis of mouse cortical development and haracterization of long non-coding RNAs
Cortical neural progenitor cells (NPCs) change their competency over time during development,giving rise to distinct cell types sequentially.Many genes that govern cortical development are now known,but it remains elusive how their temporal expression is controlled.Recently,long non-coding RNAs are found to be essential for cell-fate specification and precise gene regulation in many developmental events.In this study,strand-specific RNA sequencing studies unveil large amount of long non-coding RNAs are actively and differentially expressed across mouse cortical development.Integration of RNA sequencing data from key stages of developing mouse cortex enables us to cluster coding and non-coding transcripts into co-expression ”modules” to infer functional relationships.
Kuan Tian Wei Li Wenchen Shen Lili Mu Zhiyuan Luo Jing Liu Xiaoling Zhong Yamu Li Kuanwei Sheng Ying Liu Yan Zhou
College of Life Sciences at Wuhan University, Luojiashan, Wuhan 430072, China
国内会议
厦门
英文
71-71
2014-07-17（万方平台首次上网日期，不代表论文的发表时间）