Antitumor and antimetastatic effects of pemetrexed-loaded PEG-Peptide-PCL nanoparticles in B16 bearing mice

摘要：

We developed a novel pemetrexed-loaded PEG-Peptide-PCL nanoparticles.In this study, we evaluated the antitumor and antimetastasis effect of pemetrexed-loaded nanoparticles and examined the correlation between E-cadherin expression and lung metastasis in subcutaneous xenograft model.Compared with free pemetrexed, pemetrexed-loaded nanoparticles exhibited more efficient antitumor efficacy.Pemetrexed-loaded PEG-Peptide-PCL nanoparticles exhibited the best antitumor and antimetastasis efficacy among the four therapeutic groups.The study also indicated that there was an inverse correlation between metastasis and Ecadherin expression.These results showed pemetrexed-loaded PEG-Peptide-PCL nanoparticles may be a potent drug for tumor therapy.

作者: Nannan Lu Qin Liu Rutian Li Li Xie Jie Shen Wenxian Guan Xiaoping Qian Lixia Yu Yitao Ding Xiqun Jiang Baorui Liu

作者单位: The Comprehensive Cancer Center of Drum Tower Hospital Affiliated to Nanjing Medical University The Comprehensive Cancer Center of Drum Tower Hospital, Medical School of Nanjing University and Cli Department of Hepatobiliary Surgery, Medical School of Nanjing University The Comprehensive Cancer Center of Drum Tower Hospital Affiliated to Nanjing Medical University;The Laboratory of Mesoscopic Chemistry and Department of Polymer Science and Engineering,College of Chem

会议类型: 国内会议

会议名称: 第六届中国肿瘤内科大会

会议地点: 北京

会议语种:英文

页码: 444-444

在线出版日期: 2012-06-28（万方平台首次上网日期，不代表论文的发表时间）