MicroRNA as a novel drug target for cancer therapy
MiRNAs,a class of small,regulatory and non-coding RNA molecules,display aberrant expression patterns and functional abnormalities in all kinds of human diseases including cancers.As important emerging modulators in cellular pathways,miRNAs play a key role in tumorigenesis.Correcting these miRNAs deficiencies by either up-regulating or down-regulating miRNA function may provide a therapeutic benefit.We herein provide a brief review of miRNA in the following aspects:their possible role of miRNA as oncogenes or tumor suppressors in the pathogenesis of cancer,the abnormally expressed miRNAs in various types of human common cancers,novel drug targets and therapeutic tools for diagnosis,prognosis and treatments of human cancers was also discussed.Finally,we comment on the difficulties and challenges of miRNAs in clinical practice,and the bright perspective for future application.
microRNA abnormal expression drug target cancer biomarker
Xiaoxia Liu Li Liu Qian Xu Ping Wu Xialin Zuo Aimin Ji
南方医科大学珠江医院药剂科
国内会议
广州
英文
106-119
2013-01-12（万方平台首次上网日期，不代表论文的发表时间）