Analysis of the Constituents in Rat Serum after Oral Administration of Fufang Zhenzhu Tiaozhi Capsule by UPLC-Q-TOF-MS/MS
A rapid and sensitive UPLC/Q-TOF-MS method has been established for analysis of the constituents in rat serum after oral administration of Fufang Zhenzhu TiaoZhi (FTZ) capsule,an effective compound prescription for treating hyperlipidemia in clinic.The UPLC/MS information of samples was obtained first in FTZ preparation and FTZ-treated rat serum.Mass spectra were acquired in both negative and positive ion modes.36 constituents in rat serum after oral administration of FTZ were detected,including the alkaloids,ginsenosides,pentacyclic triterpenes and their metabolites.These chemicals were identified based on the retention time and mass spectrometry data with those of authentic standards or comparison of the literattres reports.27 prototype components originated from FTZ and 9 were the metabolites of the constituents from FTZ.These results shed a light on the potential active constituents of the complex traditional Chinese medicinal formula.
UPLC/Q-TOF-MS Serum Pharmacology Metabolite Fufang Zhenzhu Tiaozhi Capsule
Xunlong Zhong Jiao Guo Laiyou Wang Duosheng Luo Weijian Bei Yuanyuan Chen Kangqi Yan Junhui Peng
Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chines Guangzhou University of Chinese Medicine,Guangzhou,510006,P.R.China
国内会议
广州
英文
223-244
2013-01-12（万方平台首次上网日期，不代表论文的发表时间）