The Different Effect between 125I Seed Continuous Low Dose Rate Irradiation and Single External Beam Irradiation on Lung Cancer Cell Lines

摘要：

Objective To investigate the different effect and mechanism of different irradiation on A549 and H520 cell lines.Methods1.Cell culture The human lung adenocarcinoma A549 call lines and human lung squamous carcinoma H520 cell lines were maintained in RPMI-1640 supplemented with 10％ heat-inactivated fetal bovine serum,100U/ml penicillin, 100U/ml streptomycin, and 4 mM glutamine at 37 ℃ and humidified atmosphere of 5％ CO2.2.Irradiation Single external beam irradiation(EBRT)-6MV-X linear accelerator, dose rate: 400cGy/min, SSD =100cm, surface of exposure was covered by 1.5cm weighting material, sigal dose: 0, 2, 4 and8Gy.125I seed continuous low dose rate irradiation(CLDR)-125I seed of 2.5mCi, initial dose rate:2.77cGy/h, dose: 0, 2, 4 and 8Gy.

关键词： Lung cancer 125I continuous low dose rate irradiation single external beam irradiation cell cycle apoptosis double strand break repair

作者: Ang Qu Junjie Wang

作者单位: The Peking University Third Hospital

会议类型: 国内会议

会议名称: 北京大学医学部放射肿瘤学系成立大会暨北京大学第二届国际放射肿瘤学术论坛

会议地点: 北京

会议语种:英文

页码: 241-244

在线出版日期: 2012-05-23（万方平台首次上网日期，不代表论文的发表时间）