Increased Levels of Serum Lipoprotein(a)in Female Paints with Intracranial Aneurysm
Background The mechanisms of intracranial aneurysms (IAs) formation and rupture remain elusive.Elevated serum levels of Lipoprotein(a) ”Lp(a)” are associated with many vascular diseases.However, there are limited data demonstrating a relation between Lp(a) and patients with IAs.Methods An age-and sex-matched case-control study was conducted.Demographic data and plasma samples were obtained from 117 patients with angiographically proven IAs and age and sex-matched healthy controls.Serum Lp (a), fibrinogen, total cholesterol (TC), high-density lipoprotein cholesterol(HDL-C), low-density lipoprotein cholesterol (LDL-C), triglycerides (TG), and creatinine levels in IA patients and healthy subjects were studied.Results Patients with IA had significantly higher Lp(a) serum levels (median, 12 mg/dL, range,2.92-93.77 mg/dL) when compared with healthy individuals (median, 10.7 mg/dL, range, 2.1-51.6 mg/dL)(P=0.030).There were no significant differences of Lp(a) between the male patients and control subjects(median, 11.5 versus 10.8 mg/dl, P=0.606).However, serum Lp(a) levels were increased significantly in female patients with IA (median, 14.3mg/dL, range, 3.3-4.37 mg/dL) than in healthy female individuals(median, 9.4 mg/dL, range, 2.9-5.14 mg/dL) (P=0.001).A significant correlation existed between fibrinogen and lipoprotein (a) in female patients with IAs (r=0.463, p<0.0001).Conclusion: There are increased serum levels of Lp(a) in female patients with IA.The raised Lp(a) positively correlated with fibrinogen concentrations.The underlying mechanism requires further exploration.
lipoprotein(a) lipids fibrinogen intracranial aneurysm
Lin WANG Li-jiang TANG Jie-jun JIANG Xiao-feng CHEN Wei-li GE Xiao-ming HU
Department of Cardiology, Taizhou Hospital, Wenzhou Medical College, Taizhou 317000, China Department of Neurosurgery, Taizhou Hospital, Wenzhou Medical College, Taizhou 317000, China
国内会议
杭州
英文
314-320
2011-07-28（万方平台首次上网日期，不代表论文的发表时间）