Reduction of high-dose-radiation-induced delayed genotoxic effects by radioadaptive response and mild diet restriction in mice

摘要：

1.Objectives Radiation-induced adaptive response (AR) is a phenomenon manifesting as a priming low-dose-induced resistance to a subsequent challenge exposure at higher doses.Investigations of AR are expected to provide an important scientific basis for radiation risk estimates,protection and practical applications.AR has been demonstrated in a variety of in vitro and in vivo systems.In the in vitro studies,AR was reported to induce reduction of cell death,chromosomal aberrations,mutations and malignant transformation.Among the in vivo investigations,the mouse AR model (Yonezawa Effect) was characterized by significantly decreased mortality in the 30-day survival test.

关键词： Radiation Adaptive Response Mouse Diet Management Genotoxic effects

作者: Bing Wang Kaoru Tanaka Takanori Katsube Yasuharu Ninomiya Guillaume Vares Akinori Morita Tetsuo Nakajima Mitsuru Nenoi

作者单位: National Institute of Radiological Sciences,Japan The University of Tokushima Graduate School,Japan

会议类型: 国内会议

会议名称: 第二届全球华人辐射研究大会

会议地点: 苏州

会议语种:英文

页码: 93-95

在线出版日期: 2014-05-11（万方平台首次上网日期，不代表论文的发表时间）