Synthesis and Preliminary Evaluation of 99mTc-labelled monomeric and dimericFolate Derivatives viaClick Reaction

摘要：

Introduction:The folate receptor is over expressed in a wide variety of human tumors.In our study,multimer conceptwas used to synthesize FR-targeting imaging probes.Methods:The novel folate derivatives were radiolabeled with 99mTc using tricine and trisodium triphenylphosphine-3,3′,3″-trisulfonate (TPPTS) as coligands,and resulted in two complexes(99mTc-HYNIC-D0-FA1,99mTc-HYNIC-D1-FA2).Their affinity properties,cell uptake,biodistribution and micro-SPECT/CT imaging were evaluated,respectively.

作者: Zhide Guo Manli Song Pu Zhang Chang Liu Xianzhong Zhang

作者单位: Center for Molecular Imaging and Translational Medicine,State Key Laboratory of Molecular Vaccinolog Center for Molecular Imaging and Translational Medicine,State Key Laboratory of Molecular Vaccinolog

会议类型: 国内会议

会议名称: 第二届全球华人辐射研究大会

会议地点: 苏州

会议语种:英文

页码: 125-126

在线出版日期: 2014-05-11（万方平台首次上网日期，不代表论文的发表时间）