Manganese superoxide dismutase gene therapy protects against irradiation-induced intestinal injury

摘要：

　　Radiation-induced intestinal injury is a common complication in radiotherapy for solid organ malignancies in abdomen or pelvis.Currently there are no approved medical countermeasures for radiation-induced intestinal injury.Therefore,it is urgent to develop new treatments for radiation-induced intestinal injury.In the present study,we demonstrated that MSCs overexpression of a transgene for human manganese superoxide dismutase (MnSOD) could ameliorate radiation-induced intestinal syndrome.NOD/SCID mice received abdominal irradiation at a selected dose of 5 Gy,and then transfused intravenously with MnSOD-MSCs and monitored for 30-day body weight and survival.Colonization and differentiation of MnSOD-MSCs in the irradiated intestine were analyzed by histological and immunohistochemaical methods.

关键词： abdominal irradiation mesenchymal stem cells manganese superoxide dismutase small intestine injury

作者: YANG Chao CHEN Hai-Xu Li Ming WANG Li-Ying ZHANG Xiao-Mei WU Ben-Yan

作者单位: Department of Gerontal Gastroenterology,General Hospital of Chinese PLA,Beijing 100853,China Institute of Gerontology and Geriatrics,General Hospital of Chinese PLA,Beijing 10085 School of Radiation Medicine and Protection,Soochow University,Suzhou 215123 Department of Special Staff,The Second Artillery General Hospital PLA,Beijing 100088,China Department of Gastroenterology ＆ Hepatology,General Hospital of Chinese PLA,Beijing 100853,China

会议类型: 国内会议

会议名称: 第二届全球华人辐射研究大会

会议地点: 苏州

会议语种:英文

页码: 130-131

在线出版日期: 2014-05-11（万方平台首次上网日期，不代表论文的发表时间）