Radiation-induced miRNA signature promotes radioresistance of human cervical cancer cells

摘要：

Background:The mechanisms responsible for cervical cancer radioresistance are still largely unexplored.The present study aimed to identify miRNAs associated with radioresistance of cervical cancer cells.Methods:The radioresistant cervical cancer cell variants were established by repeated selection with irradiation.The miRNA profiles of radioresistant cells and their corresponding controls were analyzed and compared using microarray.Differentially expressed miRNAs were confirmed by quantitative real-time PCR.Cervical cancer cells were transfected with miRNA-specific mimics or inhibitors.Radiosensitivity of cervical cancer cells were determined using colony-forming assay.

作者: Junye Liu Guozhen Guo Jinhui Li Zhenghua Ren Yongbin Chen Xia Miao Haiyang Lang Yurong Li Dongqing Ren Jie Zhang

作者单位: Department of Radiation Medicine,Fourth Military Medical University,Xi’an 710032 Shaanxi,China

会议类型: 国内会议

会议名称: 第二届全球华人辐射研究大会

会议地点: 苏州

会议语种:英文

页码: 153-154

在线出版日期: 2014-05-11（万方平台首次上网日期，不代表论文的发表时间）