Carbon Ions-induced Murine Pulmonary Toxicity Model: Dose-response and mTOR inhibition Study
Purposes:Despite the dose improvements afforded by the Bragg peak effect in particle therapy,there are severe limitations in radiobiological precision of relative biological effectiveness (RBE) in most situations.This is because RBE varies with fractionation and LET in different tissue types.Two attempts have been made in the present study,firstly to characterize biological effects of carbon ions (12C) in whole thoracic irradiation (IR);and with the established in vivo dose-response profiling,we next sought to study the interaction of mammalian target of rapamycin (mTOR) inhibition with carbon ions combination regimen.
Carbon ions pulmonary fibrosis mTOR inhibition RBE LET BED LEM
Cheng Zhou Wilko Weichert Juergen Debus Amir Abdollahi Mahmoud Mostafa Julia Bauer Stephan Brons Liji Cao Peter Haering Andrea Mairani Katia Parodi Thomas Haberer
国内会议
苏州
英文
168-169
2014-05-11（万方平台首次上网日期，不代表论文的发表时间）