Protective Role of C60 (OH) 24-SLN-E against 60Co γ Radiation in V79 Cells and ICR Mice

摘要：

Objective:To develop a novel and stable nucleus targeting nanomaterial C60(OH) 24-SLN-E and to investigate its radioprotective effects on ICR mice exposed to 6 Gy 60Coγ radiation.Methods:C60(OH) 24-SLN-E was prepared according to the laboratory established method and the laser particle size analyzer was used to measure its particle size.SPF ICR mice were given C60(OH) 24-SLN-E intraperitoneally(i.p.) with three doses(100,10,1 μg/kg) and then survival situation in 30 days and peripheral blood cells and pathological changes of main organs were observed to evaluate the toxic effects of C60(OH) 24-SLN-E on mice.A group of SPF ICR mice(male) were pretreated with C60(OH)24-SLN-E for 7 days (daily,100μg/kg i.p.),and then exposed to a sub-lethal dose of whole body 60Co γ-irradiation.

作者: Ying Xu Baixia Yang Jiebo Zhou Hailong Li Yujie Xu

作者单位: School of Radiation Medicine and Protection(SRMP),Medical College of Soochow University,Suzhou,China School of Radiological and Interdisciplinary Sciences(RAD-X),Soochow University,Suzhou,China,215123 School of Radiation Medicine and Protection(SRMP),Medical College of Soochow University,Suzhou,China

会议类型: 国内会议

会议名称: 第二届全球华人辐射研究大会

会议地点: 苏州

会议语种:英文

页码: 207-208

在线出版日期: 2014-05-11（万方平台首次上网日期，不代表论文的发表时间）