Inflammation in the Pathogenesis of Ischemic Stroke
Ischemic stroke is a common cause of permanent disability in adults worldwide.Inflammation plays a significant role in the pathogenesis of ischemic stroke and its mechanism is complex.Both pro-inflammatory and anti-inflammatory mediators are involved in the pathogenesis of ischemic stroke,an imbalance of which leads to inflammation.Inflammatory cells from both the innate and acquired immune systems are involved in ischemic stroke-related inflammation; processes that are linked by the action of interleukin-17A (IL-17A).Although most inflammatory cells promote inflammation,T regulatory cells (Tregs) may have a protective function at the early stages of an ischemic injury,but a negative role during later stages.However,the precise mechanism of inflammation in ischemic stroke remains elusive; further understanding of it may provide new ideas for the prevention and treatment of ischemic stroke.In this review,we discuss the role of pro-inflammatory and anti-inflammatory mediators and related immune cells in the pathogenesis of ischemic stroke.
Inflammation Stroke Pathogenesis Review
PEI Jian YOU Xiao-xin FU Qinghui
Department of Acupuncture, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai200032, China
国内会议
兰州
英文
109-111
2014-07-23（万方平台首次上网日期，不代表论文的发表时间）