Rhein, a natural anthraquinone derivative, ameliorates pancreatic fibrosis in a mouse model of cerulein-induced chronic pancreatitis

摘要：

　　Anthraquinone possesses diverse biological properties including anti-inflammatory bioactivities.In cerulein-treated mice,application of Rhein (50 mg/kg/day)significantly ameliorated the severity of chronic pancreatitis and the associated fibrogenesis.Pro-inflammatory cytokines and pro-fibrotic mediators were remarkably lowered by the prolonged oral administration of Rhein.Besides anti-inflammatory activities, Rhein actually exerts strong anti-fibrotic properties against the over-production of extracellular matrix and provides effective inhibitory effect on the activation of pancreatic stellate cells.Significance: Rhein has therapeutic potential for the clinical management of pancreatic fibrosis as well as pancreatic stellate cell-related pathologies.

作者: Siu Wai Tsang Albert Sun Chi Chan Zhaoxiang Bian Hongjie Zhang Chengyuan Lin Haitao Xiao Michael Wong Hongcai Shang Baili Zhang Aiping Lu Ken Kin-Lam Yung

作者单位: School of Chinese Medicine,Hong Kong Baptist University,Kowloon Tong,Hong Kong SAR,China Hong Kong Baptist University,Kowloon Tong,Hong Kong SAR,China Tianjin University of Traditional Chinese Medicine,Tianjin,China Department of Biology,Hong Kong Baptist University,Kowloon Tong,Hong Kong SAR,China

会议类型: 国内会议

会议名称: 世界中医药学会联合会消化病专业委员会第四届消化病国际学术大会

会议地点: 郑州

会议语种:英文

页码: 323-338

在线出版日期: 2013-08-01（万方平台首次上网日期，不代表论文的发表时间）