Research on stability of in vivo sample in hepatic injury rats caused by Evodia rutaecarpa
Objective To investigate the stability of serum sample in rats with hepatic injury caused by Evodia rutaecarpa.Methods the drug-containing serum samples without pretreatment and that dried under nitrogen were stored at-20 ℃ for different time (0 d, 3 d, 5 d, 10 d and 15 d), and then detected by HPLC-DAD, respectively.Results All of the RSD values of common chromatographic peaks of serum samples dried under nitrogen were less than 20%, and that of untreated samples were partly more than 30%.Conclusion The serum samples dried under nitrogen could be stored steadily at-20 ℃ for 15 d.However,the untreated serum samples are not stable at-20 ℃ within 15 d.
Serum Stability Evodia rutaecarpa
Bao-shan Zang Wen-lan Li Xiang-ming Sun Hui Song Bei-lei Xu Lin-lin Cui
Research Center on Life Sciences and Environmental Sciences, Harbin University of Commerce,Harbin 15 College of Pharmacy, Harbin University of Commerce, Harbin 150076, China
国内会议
兰州
英文
728-735
2015-08-13（万方平台首次上网日期，不代表论文的发表时间）