MHC-CRB Mouse Projects Cardiomyopathy Defect with Dosage-dependency and Nutrition Effect

摘要：

Cre-recombinase (CRB) over-expressed mouse driven by a different promoter is normally used for conditional gene inactivation in various tissues.The specificity of this conditional knockout tool is dependent on its promoter located at the up-stream of CRB gene.A transgenic mouse MHC-CRB is the myocardial-specific Cre mouse controlled by the cardiac a myosin heavy chain promoter, which commonly used for myocardial-specific conditional removal of gene of interest.However, the toxic effect of expression of the Cre recombinase has been reported that can induce intro-chromosome rearrangements, micronuclei formation and other forms of DNA damages.

关键词： MHC-CRB Atrial-ventricle conduction defect Dosage-dependency DCM

作者: Zhongguang Li Xin Zhou Xuehong Xu Yingfeng Gao Ronghua Yang Liyang Wang Xiaofei Zhang Juncai Lv Rui Feng Jing Cui Wang Chunhui

作者单位: The Laboratory of Cell Genetics and Developmental Biology (CGDB), Shaanxi Normal University College of Medicine, Xi”An Shanxi 710119, P.R.China

会议类型: 国内会议

会议名称: 2015年中国生理学会运动生理学专业委员会会议暨“运动与血管保护”学术研讨会

会议地点: 西安

会议语种:英文

页码: 72-72

在线出版日期: 2015-09-18（万方平台首次上网日期，不代表论文的发表时间）