Dosimetric comparison using different multileaf collimators in volumetric-modulated arc therapy for malignant pleural mesothelioma
Objective: To compare the impacts of two types of multileaf collimators (MLC)”standard MLC with a width of 10 mm (sMLC) and micro-MLC with a width of 5 mm (mMLC)” on the volumetric modulated arc therapy (VMAT) planning for the malignant pleural mesothelioma.Methods and materials: Ten patients with inoperable malignant pleural mesotheliom were retrospectively planned with the sMLC and the mMLC, respectively.Dose volume histogram-based parameters of the planning target volume (PTV) ”conformity index (CI) and homogeneous index(HI)” and organs at risks (OARs) were compared between the VMAT plans with sMLC (sMLCVMAT) and those with mMLC (mMLC-VMAT).Results: The mMLC-VMAT plans were more efficient (average delivery time: 2.67min±1.49min) than sMLC-VMAT plans (average delivery time: 4.21±2.03) (p < 0.05).Also, compared to plans with the sMLC, the plans with the mMLC showed advantages in dose coverage of the PTV (CI 0.75±0.08 vs 0.73±0.09/HI 1.09±0.02 vs1.10±0.02) though the difference was not statistically significant (p>0.05).In addition, the significant dose sparing in the V20 (54.72±27.08 vs 58.52±29.30) and V30 (42.74±27.86 vs46.86±31.49) of the ipsilateral lungs were observed in the plans with the mMLC, respectively (p <0.05).Conclusions: Comparing to the sMLC-VMAT, the mMLC-VMAT not only demonstrated higher efficiencies and more optimal target coverage, but also considerably improved the dose sparing of the ipsilateral lung in the VMAT planning for malignant pleural mesothelioma.
Multileaf collimator (MLC) Mesothelioma,Volumetric modulated are therapy(VMAT)
Fuli Zhang Jun Hou Jianping Chen Huayong Jiang Weidong Xu Yadi Wang Junmao Gao Qingzhi Liu Na Lu Diandian Chen Bo Yao
Departments of Radiation Oncology, the Military General Hospital of Beijing PLA,Beijing 100700
国内会议
长沙
英文
68-72
2015-09-01（万方平台首次上网日期，不代表论文的发表时间）