Differential expression of microRNA in Anxiety Disorder (AD) patients and its association with social support and personality
Objective This study aimed to explore the differential expression of microRNA (miRNA, miR-) and its correlation with social support and personality in General Anxiety Disorder (GAD) patients.Methods A total of 76 GAD patients and 39 control participants were selected from our serial study samples to be tested for microarray analysis,and real time quantitative Polymerase Chain Reaction (qRT-PCR) verification was carried out in both patient group and control group.Correlation between miRNA expression and social support and personality were also carried out.Results 7 miRNAs were differentially expressed between patient group and control group, with miR-4505, miR-4484, miR-4674,miR-501-3p and miR-663 up-regulated,and miR-1301 and miR-432-5p down-regulated; qPCR verification revealed that 5 miRNAs (miR-1301, miR-4484, miR-4674, miR-501-3p, miR-663B, miR-4505) were significantly up-regulated; the expression of miRNA-1301 was significantly related to social support in GAD patients.Conclusions Comprehensive factors,including miRNA regulation, social support, personality and endocrinology, may be involved into the aetiology of GAD.
GAD microRNA social support personality
Jin Zhang Xinyang Sun Wei Niu Wei Guo Huimin Fan Aifang Zhong Liyi Zhang Jim Lu
213003 解放军第102医院全军心理疾病防治中心
国内会议
无锡
英文
22-25
2015-08-01（万方平台首次上网日期，不代表论文的发表时间）