Altered expression of mRNA profiles in blood of early-onset schizophrenia
To identify gene expression abnormalities in schizophrenia (SZ) ,we generated whole-genome gene expression profiles using microarrays on peripheral blood mononuclear cells (PBMCs) from 18 early-onset SZ cases and 12 controls.We detected 84 transcripts differentially expressed by affection status,with 82 genes being upregulated and 2 downregulated.We identified two gene coexpression modules (green and red) associated with SZ,including 446 genes altogether.The green module is positively correlated with SZ, encompassing predominantly over-expressed genes in SZ;while the red module was negatively correlated with disease status, involving mostly nominally under-expressed genes in SZ.CCDC 134, UBD, C 10orf67, ABIN-3, and ZIC2 are hub genes in the coexpression modules, while protein-protein interaction analysis suggests AKT1 ,CHEK1 and BRCA1 as hub genes.Our findings indicate that mRNA coexpression abnormalities may serve as a promising mechanism underlying the development of SZ.
schizophrenia mRNA coexpression microarray
Yong Xu Dai Zhang Yin Yao Shugart Guoqiang Wang Chunhui Jin Kai Zhang Jun Wang Hao Yu Fuquan Zhang Weihua Yue
Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University Institute of Mental Health, The Sixth Hospital, Peking University Beijing 100191,China;Key Laborator Unit on Statistical Genomics, Division of Intramural Research Program, National Institute of Mental Wuxi Mental Health Center, Wuxi, Jiangsu Province, China Institute of Mental Health, The Sixth Hospital, Peking University Beijing 100191,China;Key Laborator
国内会议
无锡
英文
34-38
2015-08-01（万方平台首次上网日期，不代表论文的发表时间）