Brain-derived neurotrophic factor serum levels in heroin-dependent patients after 26 weeks of withdrawal
Brain-derived neurotrophic factor (BDNF) has been implicated in the pathophysiology of heroin dependence.BDNF expression is dramatically changed during drug withdrawal,and is associated with drug withdrawal syndrome.This study aimed to explore (1) alterations of BDNF serum levels in heroin-dependent patients after long term abstinence ;and (2) the association between BDNF serum levels and protracted withdrawal syndrome.Twenty-seven male heroin-dependent patients and Twenty-eight gender-matched healthy controls were enrolled in this study.We measured BDNF serum levels at baseline and 26 weeks after heroin abstinence.Moreover, protracted withdrawal symptoms, depression and anxiety symptoms were measured by Protracted Withdrawal Symptoms of Heroin-dependent patients (PWSHA),Self-rating Depression Scale (SDS) and Self-rating Anxiety Scale (SAS), respectively.We found that baseline BDNF serum levels were significandy lower in heroin-dependent patients compared to controls (P <0.01).There was also a significantly difference in BDNF serum levels among heroin-dependent patients at baseline and 26-week follow-up (P <0.01).A positive correlation between the BDNF serum levels and protracted withdrawal syndrome at 26-week (r =0.49, P <0.05) was found but need to be confirmed in further study.The results revealed that BDNF serum level would worth paying attention to explore the possibility if it can be a biomarker as treatment outcome for heroin dependence.
Heroin Brain-derived neurotrophic factor Protracted Withdrawal Symptoms
Kai Zhang Haifeng Jiang Qiaoyang Zhang Jiang Du Yuan Wang Min Zhao
Wuxi Mental Health Center, Nanjing Medical University,214151 ,Wuxi,China ;Shanghai Mental Health Cen Wuxi Mental Health Center, Nanjing Medical University,214151 ,Wuxi,China
国内会议
无锡
英文
39-42
2015-08-01（万方平台首次上网日期，不代表论文的发表时间）