Rosuvastatin regulates the expression and activity of Krüppel-like transcription factor 2 in human umbilical vein endothelial cells

摘要：

Background Multiple evidences indicated that statins exhibit atheroprotective effects greater than those anticipated from LDL-lowering alone.Rosuvastatin has been reported to increase anticoagulants and decrease procoagulants in human umbilical vein endothelial cells (HUVECs).KLF2 was strongly implicated to be a novel nuclear mediator of statin effects in endothelial cells.We hypothesized that rosuvastatin might induce the expression and activity of KLF2 in order to protect thrombosis.

作者: MA Qian YU Miao YANG Shi-wei JIA De-an ZHOU Yu-jie

作者单位: Capital Medical University Affiliated Beijing Anzhen Hospital and Beijing Institute of Heart,Lung and Blood Vessel Diseases,Beijing,China

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 65-65

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）