Amlodipine ameliorates ischemia-induced neovascularization in diabetic rats through endothelial progenitor cells mobilization and improves cardiac function
Background Diabetes mellitus (DM) is regarded as an independent predictor of adverse outcomes in patients with acute myocardial infarction (AMI), which is in accordance with weaken ischemia-induced neovascularization attributed to impaired mobilization of endothelial progenitor cells (EPCs) from bone marrow under diabetic condition.Amlodipine,as a calcium channel blocker which could partly inhibit serum ACE activity, has been demonstrated to increase NO release, ameliorate vascular endothelial function as well as alleviate ischemia-induced heart injury and ventricular remodeling.In the study, we investigated whether amlodipine could improve the angiogenic responses in a diabetic rat model with AMI, through activation of bone marrow-EPC mobilization, and observed cardiac function after treatment.
SUN Jia-yin XU Biao
The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing,Jiangsu,China
国内会议
北京
英文
69-70
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）