Association of SNP rs3825214 and atrial fibrillation in Chinese Han population
Background Atrial fibrillation (AF) is the most common supraventricular tachycardia encountered in clinical practice associated with pronounced morbidity, mortality, and socio-economic burden.To date, mechanism of AF is still not fully understood but believed to be multifactorial including genetic predisposition.A number of genetic loci and genes related to the disorder have been reported.Recently, several genome-wide association studies (GWAS) have yielded associations between common sequence variants and ECG variables.SNP rs3825214, which is located in the last intron of the TBX5gene, was shown correlating with the PR interval, the QRS duration, the QT interval and verified significant in diseases as atrial fibrillation, advanced AV block.The postulate that variants on TBX5 influence the occurrence of AF by a new mechanism different from the most extensively accepted ion channel theory may be potential possibility.The aim of this study is to futher assess association between SNP rs3825214 and ECG parametres, AF, ventricular tachycardia (VT), as well as some arrhythmias associating with sudden cardiac death (SCD) in mainland Chinese Han population.
ZANG Xiao-biao ZHANG Shu-long TU Xin
Department of Cardiology,First Affiliated Hospital of Dalian Medical University,Dalian,China
国内会议
北京
英文
113-114
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）