Mechanism underlying the inhibitory effect of apelin-13 on glucose deprivation-induced autophagy in rat cardiomyocytes
Background Low levels of autophagy plays a protective role in cardiomyoctyes, whereas high levels or chronic autophagy can facilitate cell injury and result in the death of cells that cannot be repaired.How to effectively inhibit autophagy and attenuate myocardial damage has become a cardiovascular disease research hotspot.Apelin is highly expressed in the cardiovascular system where it exerts protective effects.The objective of this study is to investigate the effect of apelin-13 on cardiomyocyte autophagy and to determine the underlying mechanism of this effect.
JIAO Hui ZHANG Zhi MA Qing-hua FU Wei
Third Affilated Hospital of Liaoning Medical University
国内会议
北京
英文
117-117
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）