Role of the angiogenic factor Cyr61 in endothelial progenitor cells migration and tube formation in vitro
Background Recruitment and angiogenic roles of endothelial progenitor cells (EPCs) are subjected to regulation by the vascular microenvironment, which remains largely unknown.Cyr61 is a secreted matrix protein belonging to the emerging CCN family.Targeted knockout of Cyr61 gene in mice results in embryonic lethality due to placental vascular insufficiency and compromised vessel integrity.Cyr61 is able to stimulate neovascularization in both rat cornea and rabbit ischemic hindlimb in vivo and be rapidly induced by vascular endothelial cell growth factor, and promote proliferation, migration and tube formation of vascular endothelial cells (ECs) in vitro.The present study was designed to investigate the effects of mature ECs and matrix protein Cyr61 on the properties of EPCs.
YU Yang WANG Hong HUANG Lan QIN Jun GUO Rui-wei SONG Ming-bao YU Shi-yong CHEN Jian-fei
Institute of Cardiovascular Disease,Xinqiao Hospital
国内会议
北京
英文
119-119
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）