No association between pon1 gene single nucleotide polymorphisms and clopidogrel resistance in Chinese Han population

摘要：

Background Clopidogrel requires bioactivation in vivo to convert the pro-drug into its active metabolite to show its antiplatelet effects.The variability in the clinical response to clopidogrel treatment has been attributed to genetic factors,but the specific genes and mechanisms underlying clopidogrel bioactivation remain unclear.Recent studies report that paraoxonase-1(PON1) as a key enzyme play vital part in clopidogrel bioactivation.The aim of our study was to assess whether PON1 gene polymorphisms are correlation with clopidogrel resistance (CR) in patients receiving clopidogrel after percutaneous coronary intervention (PCI).

作者: LIU Teng-fei ZHANG Xiao-lin CAI Wen-zhi YAN Cheng-hui ZHANG Jian SUN Ying HAN Ya-ling

作者单位: Department of Cardiology,Institute of Cardiovascular Research of People”s Liberation Army,Shenyang Northern Hospital,Shenyang,Liaoning 110840,China

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 121-122

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）