MicroRNA-31 regulates phenotypic modulation of human vascular smooth muscle cell via its target gene CREG
Background Phenotypic modulation of vascular smooth muscle cells (VSMCs) plays a critical role in the pathogenesis of a variety of proliferative vascular diseases.We previously determined that the cellular repressor of ElA-stimulated genes (CREG) plays an important role in phenotypic modulation of VSMCs, but the mechanism of its upstream signaling regulation is not clear.Recently, microRNAs (miRNA) have been found to play a critical role in cell differentiation and proliferation via regulating its target gene.Computational analysis shows many miRNAs are able to bind to CREG mRNA 3” untranslated region (3”-UTR), suggesting that miRNA may be an upstream regulator of CREG.Thus, which miRNA bind to CREG directly and involved in CREG-mediated effect on VSMCs phenotypic modulation is an important question worth to investigate.
WANG Jie YAN Cheng-hui TAO Jie PENG Cheng-fei TIAN Xiao-xiang HAN Ya-ling
Department of Cardiology,Institute of Cardiovascular Research of People”s Liberation Army,Shenyang N Xijing Hospital Fourth Military Medical University,Xi”an,China
国内会议
北京
英文
122-122
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）