Dietary quercetin attenuates oxidant-induced endothelial dysfunction and atherosclerosis in apolipoprotein E knockout mice fed a high-fat diet

摘要：

Background Atherosclerosis is the major contributor to cardiovascular disease, the leading cause of morbidity and mortality in developed countries.Chronic endothelial dysfunction is an early and independent predictor of cardiovascular disease.Given its pivotal role in the atherogenic process, endothelial dysfunction may be regarded as a critical risk factor indicating the existence of a specific atherogenic vascular milieu.Long and short-term intervention studies using polyphenol-rich foods including fruit, cocoa, tea and red wine have shown cardiovascular protective effects.Quercetin is one of the most important polyphenols existing ubiquitously in fruit and vegetables.Recently, we have demonstrated that intake of specific flavonoids such as quercetin and epicatechin can increase nitric oxide (NO) production and improve endothelial function in healthy subjects.Heme oxygenase-1 (HO-1) is the inducible form of heme oxygenases.It exerts anti-inflammatory and antioxidant activity within the vasculature, and its induction can protect against reactive oxygen species (ROS)-induced oxidative damage.We hypothesized that chronic consumption of quercetin can improve endothelial function and attenuate atherosclerosis by up-regulating eNOS activity and increasing subsequent NO production, and inducing HO-1.Here we assess the effect of chronic quercetin consumption on HOCl-induced vascular dysfunction and atherosclerosis development in ApoE-/-and wild-type C57B1 (WT) mice fed a high fat diet.

作者: SHEN Yu Natalie C Ward Jonathan M Hodgson WANG Yu-tang Roland Stocker XU Biao Kevin D Croft

作者单位: Medical School Department of Cardiology,Drum Tower Hospital Nanjing University,Nanjing,China School of Medicine and Pharmacology,University of Western Australia,Perth,Australia Centre for Vascular Research,School of Medical Sciences (Pathology) and Bosch Institute,University o

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 126-126

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）