Txioredoxin-intracting protein mediates impairment of ischemia-induced angiogenesis in diabetic myocardium through regulation of WNT/β-CATENIN signaling

摘要：

Background Diabetes-induced impairment of collateral formation in ischemic myocardium has been demonstrated both in experimental and clinical studies, which may contribute to unfavorable prognosis among diabetic individuals.However, the underlying mechanism remains to be defined.Since Thioredoxin-interacting protein (TXNIP), an endogenous inhibitor of antioxidant thioredoxin, plays a crucial role in diabetes and its vascular complications, in present study we aim to determine whether TXNIP exerts a causative effect on impairment of myocardial ischemia-induced angiogenesis under diabetic condition, and to identify the downstream target molecule through in vivo and in vitro experiments.

作者: SHEN Ming-zhi YANG Guo-dong CHEN Jing YUAN Li-jun ZENG Chao YU Qiu-jun LI Yan YIN Tao WANG Hai-chang

作者单位: Department of Cardiology,Xijing Hospital,The Fourth Military Medical University Department of Biochemistry and Molecular Biology,Fourth Military Medical University Department of Ultrasound Diagnostics,Tangdu Hospital,Fourth Military Medical University

会议类型: 国内会议

会议名称: 第11届中国介入心脏病学大会

会议地点: 北京

会议语种:英文

页码: 127-128

在线出版日期: 2013-03-20（万方平台首次上网日期，不代表论文的发表时间）