Rosuvastatin prevents contrast-induced nephropathy in diabetic nephropathy rats
Background The aim of the present study was to assess the effects of rosuvastatin on contrast-induced nephropathy(CIN) in diabetic nephropathy rats.Methods Male SD rats, using a single intraperitoneal injection ofstreptozotocin (STZ) to create a diabetic nephropathy model.The model rats were randomly grouped into diabetic nephropathy group, contrast group and the rosuvastatin+contrast group, 10 in each group.Intravenous injection of iopromide (3500 U/kg) was given 72 hours later, the line serum creatinine testing, to determine the CIN formation.The serum total cholesterol, triglycerides, creatinine, nitric oxide, interleukin-6, and tumor necrosis factor alpha levels were analyzed.Urine samples were taken to measure the albumin/urinary creatinine ratio.Kidneys were sectioned and stained with hematoxylin/eosin and Masson”s trichrome.Immunohistochemical analysis of the renal tissue was performed to detect macrophage infiltration of the glomeruli.
DENG Jie HAN Ya-ling WU Gui-jun YANG Chen WANG Xiao-zeng
Department of Cardiology,Institute of Cardiovascular Research of People”s Liberation Army,Shenyang Northern Hospital,Shenyang,Liaoning 110840,China
国内会议
北京
英文
131-131
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）