Transplantation of human endometrial stem cells into rodent mocardial infarct mediates tissue salvage and regeneration by paracrine mechanisms
Background Human menstrual blood stem cells (MBSCs) have the potential to be ”off the shelf” clinical reagents.Here, we first studied MBSC therapy in an immunocompetent rat model of myocardial infarction (MI).Methods The cytokine expression of human MBSCs and the effect on cell proliferation and apoptosis were measured in vitro.MBSCs were intramyocardially injected into the infarct border zone of Sprague-Dawly rats 30 minutes after coronary ligation.Echocardiography, microPET and histological study were performed 4 weeks after transplantation.
JIANG Zhi HU Xin-yang YU Hong XU Yin-chuan WANG Jian-an
Department of Cardiology,Key Lab of Cardiovascular Disease,2nd Affiliated Hospital of Zhejiang University School of Medicine
国内会议
北京
英文
133-133
2013-03-20（万方平台首次上网日期，不代表论文的发表时间）